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PubMed COVID-19 Clinical Care

39911 - 39920 of 44979 results found

1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity

Date
Tuesday, April 11, 2023 - 4:00 AM
Description
Early antiviral treatments, including intravenous remdesivir (RDV), reduce hospitalization and severe disease caused by COVID-19. An orally bioavailable RDV analog may facilitate earlier treatment of non-hospitalized COVID-19 patients. Here we

Newborn Screening in a Pandemic-Lessons Learned

Date
Tuesday, April 11, 2023 - 4:00 AM
Description
The COVID-19 pandemic affected many essential aspects of public health, including newborn screening programs (NBS). Centers reported missing cases of inherited metabolic disease as a consequence of decreased diagnostic process quality during the

Evolution of the SARS-CoV-2 mutational spectrum

Date
Tuesday, April 11, 2023 - 4:00 AM
Description
SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here we examine whether this mutational process itself has changed during viral evolution. To do this, we quantify the relative rates of different types of single nucleotide